The objective of the present work is to revise inherent concepts to the practical one of the Pharmaceutical Attention in the Dispensao de Antimicrobianos in would drug. For this a bibliographical revision was become fullfilled, searching scientific articles and the current law in the site of the CRF-SP, specialized magazines and sites in the Internet as Scielo, Pub Med and academic Google. In the act of the dispensao of medicines the druggist must assure the right to the information and orientation to the medicine use. Antibiotics are natural or synthetic composites capable to inhibit the growth or to cause the death of fungos or bacteria. The resistance is considered a phenomenon that occurs as reply of the bacterium front to one I stimulate ambient as the ample antibiotic use and its presence in the environment. The promotion of the rational use of medicines are a very important component of one national medicine politics..