By the 7th day from the beginning experiment and marked the normalization of the level of plasma SM. The improvement in protein metabolism in animals of experimental group was accompanied by a decrease in severity of effects of EI. At the same time positive changes begin appear after the first, and especially after the second hemoperfusion. By 3-4 days of the experiment, the dogs disappeared signs of lethargy, appeared live reaction to the surroundings. They responded to the call and offered food, became more active and mobile. Of the 17 animals of this group survived 15.
Thus, the conduct of the TOS, antiproteinaznom hemosorbent 'Ovosorb' provides an effective correction of proteinase inhibitor- balance, which leads to the normalization of protein metabolism and cupping severe disorders of the function of vital organs and systems. Reduction of endogenous intoxication and related functional-metabolic violations after elimination from the blood of the serine protease confirms the key role of the concept of hyperactivity of the molecular mechanisms of proteolysis in the syndrome of EI in case of peritonitis. Experimentally obtained data suggest that the affine hemosorbtion biospecific sorbent is antiproteinaznom means pathogenetic correction of homeostasis in the RSE. APPLICATION biospecific ANTIPROTEINAZNOGO Hemosorbent 'OVOSORB' In KOMPLESNOM TREATMENT OF PATIENTS WITH diffuse purulent peritonitis. Studied the nature of therapeutic action and the status of certain parts of protein metabolism in connection with the application for hemosorption biospecific antiproteinaznom hemosorbent 'Ovosorb' in complex treatment of 104 patients with diffuse purulent peritonitis of appendiceal origin. Hemosorbtion carried out using glass bottles and nozzles perfusion slit.
The condition of patients in this group before turning the farm into a complex therapy did not significantly differ from that of other groups with this pathology and rated as severe or very severe. All patients had significant impairment of consciousness up to delirium. In this breathing disorder marked by shortness of breath in the form of a mixed type, marked tachycardia, unstable blood pressure with a tendency to hypotension and intestinal paresis, manifesting a dynamic picture of ileus.