State Agents

The efficiency of the action of alquilantes agents already was studied by molecular modeling and other studies of rational planning. These studies evidence the correlation in the distance enter to intramolecular in the distance of the eletroflicos centers of these alquilantes agents and of the nitrogenados nucleotdicos nucleoflicos centers. However, NH2), sulfidrila ( SH) and hidroxila ( OH) in other biological molecules, also alquilvel, explains the toxic effect of these agents (Almeida et al., 2005). The alquilantes agents are antineoplsicos pioneers, therefore, in 1942, the alquilante agent type nitrogenada mustard (mecloretamina) was used successfully to induce transitory tumoral remission in a carrying patient of linfomas. This event marked the beginning of the modern age of chemotherapy of cancer (Rajski and Williams, 1998) .2.4. Complexes metlicosO study of metallic complexes for use in the chemotherapy had great impulse after the discovery of the antitumorais properties of the cis-diaminodicloroplatina (II), cis Pt (NH3) 2Cl2, comumente called ‘ ‘ cisplatina’ ‘ same molecular formula, being that only in 1893 Werner it considered to be the two isomeric composites: the complex of Reiset corresponded to the isomer trans and of cis Peyrone to the form (Sources et al, 2005).

However, the antitumorais composite properties I contend platinum alone had been discovered more than a century after the description of composites of Reiset and Peyrone. In the end of the decade of 60, Barnet Rosenberg, a physicist, then working in the University of the State of Michigam, in the United States, looked for to study the effect of the electric field in a culture of Escherichia bacteria coli (Sources et al, 1997). Rosenberg observed that the cellular division was inhibited, and during the process, the cells of E. coli, as they could not be divided, grew forming prolongated filaments.

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